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Semaglutide and Tirzepatide (GLP-1) Compounded Medication Information

Last updated: August, 2024

Please read the following information regarding compounded GLP-1 medications (Semaglutide and Tirzepatide). If you have any questions, please speak to your provider or other licensed healthcare professional about the specific risks and benefits that may come with the use of a compounded medication. The following information is provided solely for convenience and should not be relied upon in relation to the safety and efficacy profile of any compounded medications.

Important Notice: Compounded GLP-1 drugs are permitted to be prescribed under federal law, but are not FDA-approved and do not undergo safety, effectiveness, or manufacturing review. Compounded medications are made exclusively in licensed pharmacies, their efficacy and safety profile cannot be directly compared to commercial drugs.

Thyroid Cancer Risk

  • Warning: Compounded GLP-1s may increase the risk of thyroid tumors, including thyroid cancer, based on animal studies. If you experience symptoms like a lump in your neck, hoarseness, difficulty swallowing, or breathing issues, seek medical attention immediately.

Uses

  • GLP-1s are prescribed for chronic weight management in adults as an addition to a reduced-calorie diet and increased physical activity, specifically for those with a body mass index (BMI) of 27 kg/m² or higher.

Administration

  • Semaglutide and tirzepatide are typically  administered once weekly via subcutaneous injection. Follow the dosage and administration instructions provided by your healthcare provider.

Who Should Not Use GLP-1s and Precautions?

  • Do not use if you or your family have a history of thyroid cancer, especially medullary thyroid carcinoma (MTC), or if you have Multiple Endocrine Neoplasia syndrome type 2 (MEN 2).
  • Avoid use if you are allergic to semaglutide, tirzepatide or any of its ingredients.
  • Have been diagnosed with Type 1 or Type 2 Diabetes.
  • Have a history or diagnosis of pancreatitis.
  • Suffer from gastroparesis or severe gastrointestinal issues, including slowed stomach emptying or problems digesting food.
  • Reproductive Health: Discontinue at least 2 months before planned pregnancy due to the long half-life of semaglutide and tirzepatide.
  • Pregnancy: May cause fetal harm. Discontinue upon pregnancy recognition. Do not breast feed while using semaglutide or tirzepatide. 

Drug Interactions

  • Inform your provider about all medications you take, as GLP-1s may interact with other drugs, particularly those for diabetes and weight loss.

Potential Serious Side Effects

  • Acute Pancreatitis: Severe abdominal pain, sometimes radiating to the back, may indicate pancreatitis.
  • Gallbladder Disease: Watch for symptoms like upper stomach pain, jaundice, or clay-colored stools.
  • Low Blood Sugar: Monitor blood glucose levels, especially if taking other diabetes medications.
  • Kidney Injury: Dehydration can worsen kidney issues; ensure adequate hydration.
  • Allergic Reactions: Seek immediate medical help for any signs of severe allergic reactions.
  • Mental Health: Be aware of mood changes, depression, or suicidal thoughts.

Common Side Effects

  • Nausea
  • Headache
  • Dizziness
  • Vomiting
  • Diarrhea
  • Constipation
  • Fatigue
  • Abdominal pain 
  • Indigestion
  • Belching & Flatulence
  • Gastroenteritis
  • Gastroesophageal reflux
  • Nasopharyngitis

Note: This summary does not cover all possible side effects or interactions. Consult your healthcare provider for personalized advice and visit the FDA MedWatch to report side effects.